A Facile Method with Low Hydrothermal Temperature to Synthesize TiO2 as Controlled Release Drug Delivery

作者：Liu, Di; Lin, Zi-ting; Tang, Hai-xia; Deng, Shi-ting; Bi, Yong-guang^*

来源：Physica Status Solidi (A) Applications and Materials Science, 2018, 215(13): 1800068.

DOI：10.1002/pssa.201800068

• drug loading
• homogeneous precipitation
• hydrothermal
• release kinetics
• titanium dioxide

Titania is obtained by taking titanium oxysulfate sulfuric acid complex hydrate as Ti source with a simple, energy saving process. The effect of hydrothermal time and temperature on morphology is investigated. The particle size and morphology are analyzed by X-Ray diffraction (XRD), field emission scanning electron microscopy (FESEM), energy dispersive X-ray spectroscopy (EDS), and Raman spectroscopy. Additionally, the effect of tetracycline/TiO2 ratio on drug loading capacity and encapsulation rate are studied. Zero-order kinetics, first-order kinetic, and Higuichi kinetic models are employed to investigate the drug release kinetics. The morphology of as-prepared TiO2 treated with hydrothermal temperature of 120 degrees C for 0.5h is most regular, presents microsphere shape which is composed of small particles with size of 19.36nm and shows high drug loading capacity (32.25 +/- 0.46%) and high encapsulation rate (47.63 +/- 1.41%) due to the large specific surface area of 91.0629m(2) g(-1), and it fits well with Higuichi equation with the correlation coefficients of 0.96981, illustrating that TiO2 has sustained release function. Therefore, this paper provides a convenient route to prepare TiO2 with good performance.

• 出版日期2018-7-11
• 单位广东药科大学