Noncatalytic Electrophilic Oxyalkylation of Anilines with 2-Trifluoroacetyl-1,3-benzothiazole

作者：Khodakovskiy Pavel V; Mykhailiuk Pavel K^*; Volochnyuk Dmitriy M; Tolmachev Andrey A

来源：Synthesis, 2010, (10): 1633-1638.

DOI：10.1055/s-0029-1218712

• anilines
• Friedel-Crafts alkylation
• ortho/para-substitution
• trifluoromethyl alcohols
• 1,3-benzothiazole

2-Trifluoroacetyl-1,3-benzothiazole reacts with anilines to form the corresponding trifluoromethyl-substituted alcohols. The reaction regioselectivity (ortho/para) was shown to depend strongly on the structure of the aniline. meta-Substituted anilines tend to form the corresponding ortho-substituted products, in contrary to the previous literature data.

• 出版日期2010-5