Hybrid polymeric nano-capsules loaded with gold nanoclusters and indocyanine green for dual-modal imaging and photothermal therapy

作者：Gu, Wei; Zhang, Qi; Zhang, Ting; Li, Yingying; Xiang, Jian; Peng, Rui; Liu, Jian^*

来源：Journal of Materials Chemistry B, 2016, 4(5): 910-919.

DOI：10.1039/c5tb01619c

• CANCER-CELLS
• IN-VITRO
• NANOPARTICLES
• FLUORESCENCE
• SURGERY
• SYSTEMS
• AUTOFLUORESCENCE
• PROBES

Currently there is a great need to design nano-carriers which enable multi-modal imaging of tumors and administration of therapeutics with high efficacy simultaneously. Herein we report a facile and robust approach to fabricate multifunctional nano-capsules based on double emulsions. The hybrid nano-capsules were loaded with BSA capped gold nanoclusters (AuNCs) and indocyanine green (ICG) for dual-modal imaging and effective photothermal therapy. RGD peptides were conjugated onto the surface of the hybrid nano-capsules to target cells overexpressing integrin alpha(upsilon)beta(3). We demonstrated that the as-prepared nano-capsules can be used for both one-photon and two-photon fluorescence imaging of tumor cells, and subsequent photothermal ablation with high effectiveness. The background noise of tissue autofluorescence was dramatically suppressed in the two-photon imaging mode. Therefore, it assisted a great deal to acquire images with a high signal-to-noise ratio using the hybrid nano-capsules. Due to a unique combination of the one-photon/two-photon fluorescence imaging and highly-effective photothermal properties, the hybrid nano-capsules may find broad biomedical applications as attractive theranostic nanomaterials.

• 出版日期2016
• 单位苏州大学