Alterations in physical state of silver nanoparticles exposed to synthetic human stomach fluid

作者：Rogers Kim R^*; Bradham Karen; Tolaymat Thabet; Thomas David J; Hartmann Thomas; Ma Longzhou; Williams Alan

来源：Science of the Total Environment, 2012, 420: 334-339.

DOI：10.1016/j.scitotenv.2012.01.044

• Silver nanoparticles
• Synthetic stomach fluid
• Nanoparticle characterization
• Exposure
• Bioavailability

The bioavailability of ingested silver nanoparticles (AgNPs) depends in large part on initial particle size, shape and surface coating, properties which will influence aggregation, solubility and chemical composition during transit of the gastrointestinal tract. Citrate-stabilized AgNPs were exposed to synthetic human stomach fluid (SSF) (pH 1.5) and changes in size, shape, zeta potential, hydrodynamic diameter and chemical composition were determined during a 1 h exposure period using Surface Plasmon Resonance (SPR), High Resolution Transmission Electron Microscopy/Energy Dispersive X-ray Spectroscopy (TEM/EDS), Dynamic Light Scattering (DLS) and X-ray Powder Diffraction (XRD) combined with Rietveld analysis. Exposure of AgNPs to SSF produced a rapid decrease in the SPR peak at 414 nm and the appearance of a broad absorbance peak in the near infrared (NIR) spectral region. During exposure to SSF, changes in zeta potential, aggregation and morphology of the particles were also observed as well as production of silver chloride which appeared physically associated with particle aggregates. Published by Elsevier B.V.

• 出版日期2012-3-15