Neonatal DTI early after birth predicts motor outcome in preterm infants with periventricular hemorrhagic infarction

作者：Roze Elise; Benders Manon J; Ker**ergen Karina J; van der Aa Niek E; Groenendaal Floris; van Haastert Ingrid C; Leemans Alexander; de Vries Linda S^*

来源：Pediatric Research, 2015, 78(3): 298-303.

DOI：10.1038/pr.2015.94

BACKGROUND: To determine the association between early neonatal diffusion tensor imaging (DTI) and the development of unilateral spastic cerebral palsy (USCP) in preterm infants with periventricular hemorrhagic infarction (PVHI).
METHODS: Preterm infants with PVHI were assessed with early (<= 4 wk after birth) and term-equivalent age MRI-DTI. Involvement of corticospinal tracts was assessed by visual assessment of the posterior limb of the internal capsule (PLIC) on DTI (classified asymmetrical, equivocal, or symmetrical) and by an atlas-based approach calculating fractional anisotropy asymmetry index in the PLIC. Motor outcome was assessed at >= 15 mo corrected age.
RESULTS: Seven out of 23 infants with PVHI developed USCP. Their PLIC was visually scored as asymmetrical in 6 and equivocal in 1 on the early DTI. Thirteen out of 16 infants with a symmetrical motor development had a symmetrical PLIC on early DTI, the remaining 3 were equivocal. All infants with USCP had a fractional anisotropy asymmetry index of >0.05 (optimal cut-off value) on early DTI. In infants with a symmetrical motor development (n = 16), 14 had an asymmetry index <= 0.05 while 2 had an index >0.05.
CONCLUSION: DTI in preterm infants with PVHI within a few weeks after birth is associated with later motor development.

• 出版日期2015-9