A spindle-independent cleavage furrow positioning pathway

作者：Cabernard Clemens; Prehoda Kenneth E; Doe Chris Q^*

来源：Nature, 2010, 467(7311): 91-U124.

DOI：10.1038/nature09334

The mitotic spindle determines the cleavage furrow site during metazoan cell division(1,2), but whether other mechanisms exist remains unknown. Here we identify a spindle-independent mechanism for cleavage furrow positioning in Drosophila neuroblasts. We show that early and late furrow proteins (Pavarotti, Anillin, and Myosin) are localized to the neuroblast basal cortex at anaphase onset by a Pins cortical polarity pathway, and can induce a basally displaced furrow even in the complete absence of a mitotic spindle. Rotation or displacement of the spindle results in two furrows: an early polarity-induced basal furrow and a later spindle-induced furrow. This spindle-independent cleavage furrow mechanism may be relevant to other highly polarized mitotic cells, such as mammalian neural progenitors.

• 出版日期2010-9-2