科研之友
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摘要
Introduction: Humans may be accidentally trapped in a confined atmosphere in which oxygen availability is limited. If acclimation would extend survival, hypoxic acclimation in confined spaces would be recommended. Methods: After hypoxic acclimation, an immature pig was transferred into an experimental sealed chamber. The O-2, CO2, chamber temperature, and pressure changes due to the animal's breathing were recorded. Six days acclimation (n = 3) and 3 weeks of acclimation (n = 3) were compared to control pigs (n = 3). Results: No signs of acute mountain sickness were noted in the pigs acclimated for 6 days, but some acute symptoms (which were resolved on the following day) were observed during the 3-week acclimation. The terminal partial pressure of inspired oxygen (PIO2; 3.5-3.6 kPa) was not affected by hypoxic acclimation. Oxygen consumption and CO2 production were similar in the three experimental groups. Conclusions: Our hypothesis that hypoxia acclimation would produce improved survival in a confined space was not supported by the results. It is possible that at very low inspired oxygen of 3.6 kPa, the oxygen consumption of critical life-supporting tissue reached the limit of viable cells in mammals. If this is right, no further improvement could be expected after hypoxic acclimation.
- 出版日期2008-1
- 单位中国人民解放军海军医学研究所
