DYNAMICAL PROPERTIES AND TUMOR CLEARANCE CONDITIONS FOR A NINE-DIMENSIONAL MODEL OF BLADDER CANCER IMMUNOTHERAPY

作者：Starkov K E; Bunimovich Mendrazitsky S^*

来源：Mathematical Biosciences and Engineering, 2016, 13(5): 1059-1075.

DOI：10.3934/mbe.2016030

• Dynamic modelling
• BCG
• IL-2
• combined therapy
• ultimate dynamics
• localization
• compact invariant set

Understanding the global interaction dynamics between tumor and the immune system plays a key role in the advancement of cancer therapy. Bunimovich-Mendrazitsky et al. (2015) developed a mathematical model for the study of the immune system response to combined therapy for bladder cancer with Bacillus Calmette-Guerin (BCG) and interleukin-2 (IL-2). We utilized a mathematical approach for bladder cancer treatment model for derivation of ultimate upper and lower bounds and proving dissipativity property in the sense of Levinson. Furthermore, tumor clearance conditions for BCG treatment of bladder cancer are presented. Our method is based on localization of compact invariant sets and may be exploited for a prediction of the cells populations dynamics involved into the model.

• 出版日期2016-10