An inflammatory review of glucocorticoid actions in the CNS

作者：Sorrells Shawn F^*; Sapolsky Robert M

来源：Brain, Behavior, and Immunity, 2007, 21(3): 259-272.

DOI：10.1016/j.bbi.2006.11.006

• glucocorticoids
• corticosterone
• dexamethasone
• RU-486
• chronic stress
• acute stress
• DTH
• inflammation
• LPS
• stroke
• ischemia
• cytokines
• NF kappa B
• brain
• central nervous system

In recent years.. the classic view that glucocorticoids, the adrenal steroids secreted during stress, are universally anti-inflammatory has been challenged at a variety of levels. It was first observed that under some circumstances, acute GC exposure could have pro-inflammatory effects on the peripheral immune response. More recently, chronic exposure to GCs has been found to have pro-inflammatory effects on the specialized immune response to injury in the central nervous system. Here we review the evidence that in some cases, glucocorticoids can increase pro-inflammatory cell migration, cytokine production, and even transcription factor activity in the brain. We consider how these unexpected effects of glucocorticoids can co-exist with their well-established anti-inflammatory properties, as well as the considerable clinical implications of these findings.

• 出版日期2007-3