Association of Mitral Annular Calcification with Left Ventricular Mechanics: A Speckle Tracking Study

作者：Gokdeniz Tayyar^*; Boyaci Faruk; Hatem Engin; Bektas Huseyin; Kalaycioglu Ezgi; Gursoy Mustafa Ozan; Aykan Ahmet Cagri; Yildiz Banu Sahin; Altintas Bernas

来源：Echocardiography-A Journal of Cardiovascular Ultrasound and Allied Techniques, 2015, 32(9): 1374-1383.

DOI：10.1111/echo.12861

• mitral annular calcification
• left ventricular mechanical functions
• two-dimensional speckle tracking echocardiography
• subclinical left ventricle systolic dysfunction

BackgroundMitral annular calcification (MAC) is a common echocardiographic finding in clinical practice and is associated with cardiovascular risk factors and atherosclerosis. However, data regarding left ventricular (LV) functions are lacking. We aimed to evaluate the relationship between MAC and LV mechanical functions with the utility of two-dimensional speckle tracking echocardiography (2DSTE).
MethodsThe study involved 91 patients with MAC and 48 control subjects. Mitral annular thickness of 1-2mm was reported as mild, 2-5mm as moderate, and >5mm as severe MAC. All patients underwent 2D echocardiography.
ResultsMAC was observed in 91 (65.5%) patients. Of LV diastolic parameters, E/Em ratio, LAVI, LV mass index, and t-LV UR were increased. Of LV systolic parameters, GLS and Sm were decreased, whereas Ar, Ar-rate (systole), peak LV twist, peak LV twist rate, LV-tor, and MPI were increased, which were all correlated with presence and severity of MAC. Multivariate linear regression analysis showed that LV mass index (=0.225, P=0.012), t-LV UR (=0.370, P<0.001), LV mass index (=0.183, P=0.025), MPI (=0.288, P<0.001), and GLS (=-0.385, P<0.001) were significantly associated with MAC severity.
ConclusionThe presence and severity of MAC is associated with impaired LV systolic and diastolic functions. Therefore, preventive strategies might be taken in patients with MAC to avoid LV systolic and diastolic dysfunction.

• 出版日期2015-9