Methotrexate causes acute hyperplasia of enterochromaffin cells containing substance P in the intestinal mucosa of rats

作者：Machida Takuji; Takano Yuho; Iizuka Kenji; Machida Maiko; Hirafuji Masahiko^*

来源：Journal of Pharmacological Sciences, 2017, 133(3): 190-193.

DOI：10.1016/j.jphs.2017.02.009

• Methotrexate
• Substance P
• Enterochromaffin cells

This study aimed to investigate the acute and chronic effect of methotrexate on the intestinal substance P metabolism after a single administration to rats. Methotrexate caused a significant increase in the number of substance P-containing cells in the ileal mucosa both at 24 and 96 h. Most of enterochromaffin cells expressing L-tryptophan hydroxylase contained substance P. The expression of Tac1 mRNA was increased by methotrexate at 24 h, but not at 96 h. Thus, methotrexate causes acute hyperplasia of enterochromaffin cells in the intestinal mucosa of rats with a transient increase in the production of substance P. (C) 2017 The Authors. Production and hosting by Elsevier B.V. on behalf of Japanese Pharmacological Society. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

• 出版日期2017-3