A chiral iron(II)-pybox catalyst stable in aqueous media. Asymmetric Mukaiyama-aldol reaction

作者：Jankowska Joanna; Paradowska Joanna; Mlynarski Jacek^*

来源：Tetrahedron Letters, 2006, 47(30): 5281-5284.

DOI：10.1016/j.tetlet.2006.05.140

• asymmetric synthesis
• Mukaiyama reaction
• water
• iron complex

Among various transition metals, iron is nontoxic, cheap and hence of great potential synthetic use. We report herein a water stable chiral Lewis acid containing an iron(11) ion and a pybox-type ligand. The resulting cationic aqua complex of C-2-symmetry is an effective Lewis acid catalyst for asymmetric Mukaiyama-aidol reactions in aqueous media. The aldol products have been obtained in good yields, syn-diastereoselectivities and ca. 70% levels of enantioselectivity.

• 出版日期2006-7-24