A mitochondria-targeted nitric oxide donor triggered by superoxide radical to alleviate myocardial ischemia/reperfusion injury

作者：Hou, Jingli; He, Haiyan; Huang, Saipeng; Qian, Meng; Wang, Jie; Tan, Xiaoli; Han, Guifang; Song, Yuguang^*; Xu, Zhelong^*; Liu, Yangping^*

来源：Chemical communications, 2019, 55(9): 1205-1208.

DOI：10.1039/c8cc07304j

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A novel mitochondria-targeted superoxide-responsive nitric oxide donor was developed by incorporation of diphenylphosphinyl and triphenylphosphonium groups into diazeniumdiolate,enabling remarkable protection against ischemia/reperfusion injury in H9c2 cells and isolated rat hearts.

• 出版日期2019-1-28
• 单位西北大学; 天津医科大学