Preparation of C-5-substituted 6,5 '-O-anhydrouridine by Sn-Pd transmetallation-coupling process and their use

作者：Mieczkowski Adam; Blu Jerome; Roy Vincent; Agrofoglio Luigi A^*

来源：Tetrahedron, 2009, 65(47): 9791-9796.

DOI：10.1016/j.tet.2009.09.075

The palladium-catalyzed reaction of 5-tributylstannyluridine derivative (9) with a variety of aryl, vinyl halides provides an efficient method for the synthesis of the corresponding 5-substituted 6,5'-O-anhydrouridines. Additionally the 5-fluoro 6,5'-O-anhydrouridine (16) via fluoro-destannylation with Selectfluor is described. A dialkylphosphonate moiety was then introduced at C5 from the allyl derivative 10a under cross-metathesis conditions.

• 出版日期2009-11-21