Dissociations within short-term memory in GluA1 AMPA receptor subunit knockout mice

作者：Taylor Amy M; Niewoehner Burkhard; Seeburg Peter H; Sprengel Rolf; Rawlins J Nicholas P; Bannerman David M; Sanderson David J^*

来源：Behavioural Brain Research, 2011, 224(1): 8-14.

DOI：10.1016/j.bbr.2011.05.016

• AMPA receptors
• Conditional learning
• Trace conditioning
• Non-spatial memory
• Spatial memory

GluA1 AMPA receptor subunit knockout mice display a selective impairment on short-term recognition memory tasks. In this study we tested whether GluA1 is important for short-term memory that is necessary for bridging the discontiguity between cues in trace conditioning. GluA1 knockout mice were not impaired at using short-term memory traces of T-maze floor inserts, made of different materials, to bridge the temporal gap between conditioned stimuli and reinforcement during appetitive discrimination tasks. Thus, different aspects of short-term memory are differentially sensitive to GluA1 deletion. This dissociation may reflect processing of qualitatively different short-term memory traces. Memory that results in performance of short-term recognition (e.g. for objects or places) may be different from the memory required for associative learning in trace conditioning.

• 出版日期2011-10-10
• 单位河北医科大学