A microwave-assisted multicomponent synthesis of substituted 3,4-dihydroquinazolinones

作者：Stevens Marc Y; Wieckowski Krzysztof; Wu Peng; Sawant Rajiv T; Odell Luke R^*

来源：Organic and Biomolecular Chemistry, 2015, 13(7): 2044-2054.

DOI：10.1039/c4ob02417f

A microwave-assisted, multicomponent protocol for the synthesis of substituted 3,4-dihydroquinazolinones via a novel cascade imine/cyclization/aza-Henry reaction sequence is reported. Starting from o-formyl carbamates, a series of structurally diverse 3,4-dihydroquinazolinones was synthesized via a cyclic iminium ion intermediate in moderate to excellent yields. Notably, the reaction is fast, flexible, simple to perform and tolerates a variety of functional groups.

• 出版日期2015