Neonatal Herpes Simplex Virus Infection

作者：James Scott H; Kimberlin David W^*

来源：Infectious Disease Clinics of North America, 2015, 29(3): 391-+.

DOI：10.1016/j.idc.2015.05.001

• Neonatal herpes
• Herpes simplex virus
• Genital herpes
• Mother-to-child transmission
• Antiviral therapy

Herpes simplex virus (HSV) 1 and HSV-2 infections are highly prevalent worldwide and are characterized by establishing lifelong infection with periods of latency interspersed with periodic episodes of reactivation. Acquisition of HSV by an infant during the peripartum or postpartum period results in neonatal HSV disease, a rare but significant infection that can be associated with severe morbidity and mortality, especially if there is dissemination or central nervous system involvement. Diagnostic and therapeutic advances have led to improvements in mortality and, to a lesser extent, neurodevelopmental outcomes, but room exists for further improvement.

• 出版日期2015-9