Comparison of gram-negative and gram-positive hematogenous pyogenic spondylodiscitis: clinical characteristics and outcomes of treatment

作者：Lee Ching Yu; Wu Meng Huang; Cheng Chin Chang; Huang Tsung Jen; Huang Tsung Yu; Lee Chien Yin; Huang Jou Chen; Li Yen Yao

来源：BMC Infectious Diseases, 2016, 16(1): 735.

DOI：10.1186/s12879-016-2071-4

• Gram-negative infection
• Gram-positive infection
• Hematogenous pyogenic spondylodiscitis

Background: To the best of our knowledge, no study has compared gram-negative bacillary hematogenous pyogenic spondylodiscitis (GNB-HPS) with gram-positive coccal hematogenous pyogenic spondylodiscitis (GPC-HPS) regarding their clinical characteristics and outcomes.
Methods: From January 2003 to January 2013, 54 patients who underwent combined antibiotic and surgical therapy in the treatment of hematogenous pyogenic spondylodiscitis were included.
Results: Compared with 37 GPC-HPS patients, the 17 GNB-HPS patients were more often found to be older individuals, a history of cancer, and a previous history of symptomatic urinary tract infection. They also had a less incidence of epidural abscess formation compared with GPC-HPS patients from findings on magnetic resonance imaging (MRI). Constitutional symptoms were the primary reasons for initial physician visits in GNB-HPS patients whereas pain in the affected spinal region was the most common manifestation in GPC-HPS patients at initial visit. The clinical outcomes of GNB-HPS patients under combined surgical and antibiotic treatment were not different from those of GPC-HPS patients. In multivariate analysis, independent predicting risk factors for GNB-HPS included a malignant history and constitutional symptoms and that for GPC-HPS was epidural abscess.
Conclusions: The clinical manifestations and MRI presentations of GNB-HPS were distinguishable from those of GPC-HPS.

• 出版日期2016-12-6
• 单位长春大学