An Osteoconductive Antibiotic Bone Eluting Putty with a Custom Polymer Matrix

作者：Curley John; Hasan Mohammad Raquibul; Larson Jacob; Brooks Benjamin D; Liu Qianhui; Jain Tanmay; Joy Abraham; Brooks Amanda E

来源：Polymers, 2016, 8(7): 247.

DOI：10.3390/polym8070247

• osteomyelitis
• controlled drug release
• bone void filler
• putty
• pharmacokinetics
• pendant-functionalized diol

With the rising tide of antibiotic resistant bacteria, extending the longevity of the current antibiotic arsenal is becoming a necessity. Developing local, controlled release antibiotic strategies, particularly for difficult to penetrate tissues such as bone, may prove to be a better alternative. Previous efforts to develop an osteoconductive local antibiotic release device for bone were created as solid molded composites; however, intimate contact with host bone was found to be critical to support host bone regrowth; thus, an osteocondconductive antibiotic releasing bone void filling putty was developed. Furthermore, a controlled releasing polymer matrix was refined using pendant-functionalized diols to provide tailorable pharmacokinetics. In vitro pharmacokinetic and bioactivity profiles were compared for a putty formulation with an analogous composition as its molded counterpart as well as four new pendant-functionalized polymers. A best-fit analysis of polymer composition in either small cylindrical disks or larger spheres revealed that the new pendant-functionalized polymers appear to release vancomycin via both diffusion and erosion regardless of the geometry of the putty. In silico simulations, a valuable technique for diffusion mediated controlled release models, will be used to confirm and optimize this property.

• 出版日期2016-7