A vestige of a prebiotic bonding machine is functioning within the contemporary ribosome

作者：Krupkin Miri; Matzov Donna; Tang Hua; Metz Markus; Kalaora Rinat; Belousoff Matthew J; Zimmerman Ella; Bashan Anat; Yonath Ada^*

来源：Philosophical Transactions of the Royal Society B-Biological Sciences, 2011, 366(1580): 2972-2978.

DOI：10.1098/rstb.2011.0146

• proto-ribosome
• ribosomal symmetrical region
• peptide bond formation
• RNA world

Based on the presumed capability of a prebiotic pocket-like entity to accommodate substrates whose stereochemistry enables the creation of chemical bonds, it is suggested that a universal symmetrical region identified within all contemporary ribosomes originated from an entity that we term the 'proto-ribosome'. This 'proto-ribosome' could have evolved from an earlier machine that was capable of performing essential tasks in the RNA world, called here the 'pre-proto-ribosome', which was adapted for producing proteins.

• 出版日期2011-10-27