Analeptic agent from microbes upon cyanide degradation

作者：Murugesan Thandeeswaran; Durairaj Nisshanthini; Ramasamy Mahendran; Jayaraman Karunya; Palaniswamy Muthusamy; Jayaraman Angayarkanni^*

来源：Applied Microbiology and Biotechnology, 2018, 102(4): 1557-1565.

DOI：10.1007/s00253-017-8674-x

• Microbial metabolism
• Toxins
• Cyanide degradation
• Cyanide monooxygenase
• Pterin
• Neurotransmitter

Microbes being the initial form of life and ubiquitous in occurrence, they adapt to the environment quickly. The microbial metabolism undergoes alteration to ensure conducive environment either by degrading the toxic substances or producing toxins to protect themselves. The presence of cyanide waste triggers the cyanide degrading enzymes in the microbes which facilitate the microbes to utilize the cyanide for its growth. To enable the degradation of cyanide, the microbes also produce the necessary cofactors and enhancers catalyzing the degradation pathways. Pterin, a cofactor of the enzyme cyanide monooxygenase catalyzing the oxidation of cyanide, is considered to be a potentially bioactive compound. Besides that, the pterins also act as cofactor for the enzymes involved in neurotransmitter metabolism. The therapeutic values of pterin as neuromodulating agent validate the necessity to pursue the commercial production of pterin. Even though chemical synthesis is possible, the non-toxic methods of pterin production need to be given greater attention in future.

• 出版日期2018-2