Comparison of the anti-inflammatory effects of fluorometholone 0.1% combined with levofloxacin 0.5% and tobramycin/dexamethasone eye drops after cataract surgery

作者：Chen, Pei-Qing^*; Han, Xue-Mei; Zhu, Ya-Nan; Xu, Jia

来源：International Journal of Ophthalmology, 2016, 9(11): 1619-1623.

DOI：10.18240/ijo.2016.11.13

• fluorometholone
• levofloxacin
• tobramycin/dexamethasone
• phacoemulsification
• inflammation

AIM: To compare the combination of fluorometholone 0.1% and levofloxacin 0.5% to tobramycin/dexamethasone eye drops in controlling inflammation and preventing infection after phacoemulsification with an intraocular lens implantation. @@@ METHODS: Sixty eyes from 60 patients undergoing cataract phacoemulsification were randomized into two groups; half of the patients were treated with fluorometholone (6 times/d) combined with levofloxacin (4 times/d), while the other half were treated with tobramycin/dexamethasone (4 times/d) eye drops for one week. Preoperative and postoperative intraocular pressure, aqueous flare, corneal thickness, and signs and symptoms were recorded before the operation and 1wk following treatments. @@@ RESULTS: There were no statistically significant differences between the two groups in corneal thickness (P >= 0.629), aqueous flare (P >= 0.398), and signs and symptoms scores (P >= 0.350) at each time point. Ocular hypertension was only observed in two eyes in the tobramycin/dexamethasone group. @@@ CONCLUSION: Fluorometholone combined with levofloxacin treatment shows comparable efficacy but without the tendency to increase intraocular pressure; thus, it might be a better regimen for postoperative use.

• 出版日期2016-11-18
• 单位浙江中医药大学; 浙江医院; 浙江大学