Non-culprit plaque characteristics in acute coronary syndrome patients with raised hemoglobinA1c: an intravascular optical coherence tomography study

作者：Zhang, Shaotao; Dai, Jiannan; Jia, Haibo; Hu, Sining; Du, Hongwei; Li, Ning; Zou, Yongpeng; Zou, Yanan; Jing, Shenhong; Wang, Yan; Sun, Rong; Yu, Bo^*

来源：Cardiovascular Diabetology, 2018, 17(1): 90.

DOI：10.1186/s12933-018-0729-5

• Pre-diabetes
• Raised hemoglobinA1c
• Optical coherence tomography
• Coronary artery disease

Background: Raised hemoglobinA1c (HbA1c) is an indicator of pre-diabetes, which is associated with increased risk of coronary artery disease. However, the detailed morphological characteristics of non-culprit plaques in acute coronary syndrome (ACS) patients remain largely unknown. @@@ Methods: A total of 305 non-culprit plaques from 216 ACS patients were analyzed by intravascular optical coherence tomography. These patients were divided into three groups according to the serum glycosylated hemoglobin level: normal HbA1c (<5.7%), pre-diabetes with raised HbA1c (5.7-6.4%) and diabetes mellitus (DM). @@@ Results: Plaques in patients with raised HbA1c had a longer lipid length (17.0 +/- 8.3 mm vs. 13.9 +/- 7.2 mm, P = 0.004) and greater lipid index (2775.0 +/- 1694.0 mm degrees vs. 1592.1 +/- 981.2 mm degrees, P = 0.001) than those with normal HbA1c but were similar to DM. The prevalence of calcification in patients with raised HbA1c was significantly higher (38.7% vs. 26.3%, P = 0.048) than normal HbA1c but was similar to DM. The percentage of macrophage infiltration in the DM group was higher than that in the normal HbA1c group (20.5% vs. 7.4%, P = 0.005). @@@ Conclusions: Compared to patients with normal HbA1c, the non-culprit plaques in ACS patients with raised HbA1c had more typical vulnerable features but were similar to DM.

• 出版日期2018-6-15
• 单位哈尔滨医科大学