Heme oxygenase-1 polymorphism is not associated with risk of colorectal cancer: a Danish prospective study

作者：Andersen Vibeke^*; Christensen Jane; Overvad Kim; Tjonneland Anne; Vogel Ulla

来源：European Journal of Gastroenterology and Hepatology, 2011, 23(3): 282-285.

DOI：10.1097/MEG.0b013e3283417f76

• carcinogenesis
• cohort
• epidemiology
• gene-environment interaction
• population-based
• prospective study
• red and processed meat

Objective Intake of red and processed meat confers risk of colorectal cancer (CRC). We wanted to test whether heme in meat promotes carcinogenesis.
Methods Heme oxygenase-1 (HO-1, HMOX1) A-413T (rs2071746) was assessed in a nested case-cohort study of 383 CRC cases and 763 randomly selected participants from a prospective study of 57 053 individuals. Incidence rate ratios and 95% confidence intervals were calculated.
Results No association was found between the HO-1 polymorphism and CRC (P value for trend for the fully adjusted estimates = 0.29). No interaction with meat intake was found (P value for interaction = 0.55).
Conclusion The studied HO-1 polymorphism was not associated with risk of CRC suggesting that heme from meat is not important in CRC development.

• 出版日期2011-3