Diagnostic approach to autoimmune hepatitis

作者：Muratori Paolo^*; Lenzi Marco; Cassani Fabio; Lalanne Claudine; Muratori Luigi

来源：Expert Review of Clinical Immunology, 2017, 13(8): 769-779.

DOI：10.1080/1744666X.2017.1327355

• Autoimmune hepatitis
• autoantibodies
• antinuclear antibodies
• anti smooth muscle antibodies
• pattern
• liver kidney microsome type 1
• interface hepatitis
• hypergammaglobulinemia

Introduction: Autoimmune hepatitis (AIH) is a chronic inflammatory liver disease which, if left without treatment, can evolve into cirrhosis and possibly liver failure. The diagnosis of AIH is hampered by the lack of specific and reliable markers of the disease and a number of clinical, biochemical, immunological, histological and genetic factors should be considered to reach a confident diagnosis
Areas covered: Clinical expression of AIH, histological features, serological and genetic profiles, differential diagnosis, overlap with other autoimmune liver diseases, assessed on the basis of personal experience and review of published literature in the last 10years through a systematic Medline search (keywords: autoimmune hepatitis, diagnosis)
Expert commentary: Notwithstanding numerous efforts to identify simple and reliable markers of the disease, the diagnosis of AIH is still based on the combination of histological, immunological and biochemical features and often can represent a real challenge for the hepatologist.

• 出版日期2017