Black Phosphorus: Bioactive Nanomaterials with Inherent and Selective Chemotherapeutic Effects

作者：Zhou, Wenhua; Pan, Ting; Cui, Haodong; Zhao, Zhen; Chu, Paul K.; Yu, Xue-Feng^*

来源：Angewandte Chemie - International Edition, 2019, 58(3): 769-774.

DOI：10.1002/anie.201810878

• anti-tumor activity
• bioactivity
• black phosphorus
• selective chemotherapy
• two-dimensional materials

Black phosphorus nanosheets (BPs) are demonstrated to be highly bioactive anti-cancer agents because of their inherent and selective chemotherapeutic effects. Fast intracellular biodegradation of BPs and acute elevation of phosphate anions were observed from different types of cancer cells due to the stronger intracellular oxidative stress and accelerated energy metabolism, but normal cells are not affected. Selective biodegradation of BPs induced G2/M phase arrest and subsequent apoptosis- and autophagy-mediated cell death in cancer cells but not normal cells. The selectivity was superior to that of the traditional chemotherapeutic agent, doxorubicin (DOX). In vivo assessment confirmed the efficiency of BPs in suppressing tumor growth. This study provides insights into nanostructured bioactive anti-cancer agents and reveals a new direction for nanomedicine research.

• 出版日期2019-1-14
• 单位中国科学院; 中国科学院深圳先进技术研究院