Alternative Means of Estimating I-131 Maximum Permissible Activity to Treat Thyroid Cancer

作者：Nichols Kenneth J^*; Robeson William; Yoshida Hay Miyuki; Zanzonico Pat B; Leveque Fritzgerald; Bhargava Kuldeep K; Tronco Gene G; Palestro Christopher J

来源：Journal of Nuclear Medicine, 2017, 58(10): 1588-1595.

DOI：10.2967/jnumed.117.192278

• dosimetry
• radioactive iodine
• therapy
• thyroid cancer

To protect bone marrow from overirradiation, the maximum permissible activity (MPA) of I-131 to treat thyroid cancer is that which limits the absorbed dose to blood (as a surrogate of marrow) to less than 200 cGy. The conventional approach (method 1) requires repeated gamma-camera whole-body measurements along with blood samples. We sought to determine whether reliable MPA values can be obtained by simplified procedures. Methods: Data acquired over multiple time points were examined retrospectively for 65 thyroid cancer patients, referred to determine 131I uptake and MPA for initial treatment after thyroidectomy (n = 39), including 17 patients with compromised renal function and 22 patients with known (n 5 16) or suspected (n = 6) metastases. The total absorbed dose to blood(D-Total) was the sum of mean whole-body gamma-ray dose component (D-gamma) from uncollimated gamma-camera measurements and dose due to beta emissions (D-beta) from blood samples. Method 2 estimated DTotal from Db alone, method 3 estimated DTotal from Dg alone, and method 4 estimated DTotal from a single 48-h gamma-camera measurement. MPA was computed as 200 cGy/D-Total for each DTotal estimate. Results: Method 2 had the strongest correlation with conventional method 1 (r = 0.98) and values similar to method 1 (21.0 +/- 6 13.7 cGy/GBq vs. 21.0 +/- 14.1 cGy/GBq, P = 0.11), whereas method 3 had aweaker (P = 0.001) correlation (r = 0.94) and method 4 had the weakest (P < 0.0001) correlation (r = 0.69) and lower dose (16.3 +/- 6 14.8 cGy/GBq, P < 0.0001). Consequently, correlation with method 1 MPA was strongest for method 2 MPA (r = 0.99) and weakest for method 4 (r = 0. 75). Method 2 and method 1 values agreed equally well regardless of whether patients had been treated with I-131 previously or had abnormal renal function. Conclusion: Because MPA based on blood measurements alone is comparable to MPA obtained with combined body counting and blood sampling, blood measurements alone are sufficient for determining MPA.

• 出版日期2017-10