Antimicrobial properties of hemokinin-1 against strains of Pseudomonas aeruginosa

作者：Berger Alexandra^*; Tran Anne H; Dedier Helen; Gardam Michael A; Paige Christopher J

来源：Life Sciences, 2009, 85(19-20): 700-703.

DOI：10.1016/j.lfs.2009.09.011

• Hemokinin-1
• Substance P
• Tachykinin peptide
• Pseudomonas aeruginosa
• Antimicrobial activity

Aims: In this study, we examined whether hemokinin-1, the newest member of the tachykinin family and a close relative of substance P, has antimicrobial properties which have been attributed to other neuropeptides including substance P.
Main methods: Top agar assays were performed to determine the antimicrobial activity of hemokinin-1 and substance P against various microorganisms.
Key findings: Here we provide evidence that hemokinin-1 peptide possesses antimicrobial properties against some strains of Pseudomonas aeruginosa, while substance P was only marginally effective.
Significance: Our Study is the first to link hemokinin-1 to the essential role of defending the body against microbial challenges and adds hemokinin-1 to the list of potential drugs that Could help in the fight against P. aeruginosa, an opportunistic human pathogen.

• 出版日期2009-11-4