Accelerating lead optimization of chromone carboxamide scaffold throughout microwave-assisted organic synthesis

作者：Cagide Fernando; Reis Joana; Gaspar Alexandra; Borges Fernanda^*

来源：Tetrahedron Letters, 2011, 52(48): 6446-6449.

DOI：10.1016/j.tetlet.2011.09.095

• Chromone carboxamide
• Microwave-assisted organic synthesis
• Lead optimization program
• PyBOP
• PCl3O

Microwave irradiation offers a considerable advantage over conventional synthesis with rate enhancements and cleaner reactions. Accordingly, a new microwave-assisted method for the synthesis of functionalized chromones was developed allowing the obtention of a library of chromone carboxamides. The method has been shown to present several advantages including operational simplicity, good performance, significant reduction in reaction time, less formation of by-products, and easier work-up.

• 出版日期2011-11-30