ALZHEIMER DISEASE 'Generation Next' in Alzheimer disease genetic studies

作者:Apostolova Liana G*
来源:Nature Reviews Neurology, 2013, 9(8): 422-423.
DOI:10.1038/nrneurol.2013.133

摘要

A recent study has used whole-exome sequencing, an 'extreme trait' design and imaging genetics to identify coding variants associated with hippocampal volume loss in Alzheimer disease. The research highlights the utility of next-generation sequencing and association studies involving quantitative traits for discovery of disease-related variants in neurodegeneration.

  • 出版日期2013-8