Derivatization method for sensitive determination of fluorotelomer alcohols in sediment by liquid chromatography-electrospray tandem mass spectrometry

作者：Peng Hui; Hu Kejun; Zhao Fanrong; Hu Jianying^*

来源：Journal of Chromatography A, 2013, 1288: 48-53.

DOI：10.1016/j.chroma.2013.02.085

• Derivatization
• LC-ESI-QTOF-MS
• CID-MS/MS
• Perfluorinated compounds
• Fluorotelomer alcohol

Fluorotelomer alcohols (FTOHs) are the main precursors of environmentally ubiquitous perfluorinated acids, and determination of FTOHs at low concentrations presents significant challenges. In this study, a new liquid chromatography-electrospray mass spectrometry (LC-ESI-MS) method in conjunction with low-energy collision dissociation tandem mass spectrometry (CID-MS/MS) was developed by employing an optimized derivatization reaction with dansyl chloride (DNS) in acetonitrile under catalysis of 4-(dimethylamino)-pyridine (DMAP). The instrument detection limits (IDLs) of the newly developed method were 0.014, 0.015, 0.014, 0.0075 and 0.0093 mu g/L for 4:2 FTOH, 6:2 FTOH, 8:2 FTOH, 10:1 FTOH and 10:2 FTOH respectively, which were 7.5-241 times lower than those without derivatizaiton and 57-357 times lower than previous GC/MS method. The method was successfully applied to analyze FTOHs in sediments combined with WAX and silica cartridges cleanup. The overall method recoveries were from 67 +/- 6.0% to 83 +/- 9.4% with matrix effects of <15%. The limits of quantification for all FTOHs were 0.017-0.060 ng/g dry weight (dw). The method was applied to analyze six marine sediment samples from Liaodong Bay, China. All FTOHs except for 10:1 FTOH were detected, and the total concentrations of FTOHs were 0.19-0.52 ng/g dw. The developed method provides a new method to sensitively determine FTOHs in environmental matrices.

• 出版日期2013-5-3
• 单位北京大学