A Green Synthesis of Highly Functionalized 3-amino-2-phenylsulfonyl-1-alkyl/aryl-1H-pyrazolo[1,2-b]ph thalazine-5,10-diones and Their Reduction and Photophysical Studies

作者：Shi, Xin; Ding, Maohua; Li, Conghao; Wang, Wang; Guo, Hongyun^*

来源：Journal of Heterocyclic Chemistry, 2018, 55(2): 440-446.

DOI：10.1002/jhet.3061

• MULTICOMPONENT REACTIONS
• PHTHALAZINE DERIVATIVES
• REVERSE-TRANSCRIPTASE
• ANTITUMOR-ACTIVITY
• PYRAZOLE
• HETEROCYCLES
• INHIBITORS
• FACILE
• DESIGN
• ETHERS

3-Amino-2-benzenesulfonyl-1-alkyl/aryl-1H-pyrazolo[1,2-b]phthalazine-5,10-dione derivatives were synthesized by the one-pot, three-component condensation of phthalhydrazide, aldehydes, and (phenylsulfonyl)acetonitrile in EtOH using 2-hydroxyethylammonium acetate as catalyst. The advantages of this method include environmental friendliness, easy work-up, and excellent yields. The reduction of some products and photophysical properties were also investigated.

• 出版日期2018-2
• 单位浙江工业大学