A hybrid approach to predict the relationship between tablet tensile strength and compaction pressure using analytical powder compression

作者：Persson Ann Sofie^*; Alderborn Goran

来源：European Journal of Pharmaceutics and Biopharmaceutics, 2018, 125: 28-37.

DOI：10.1016/j.ejpb.2017.12.011

• Prediction
• Compression
• Compaction
• Tablet tensile strength
• Yield pressure

The objective was to present a hybrid approach to predict the strength-pressure relationship (SPR) of tablets using common compression parameters and a single measurement of tablet tensile strength. Experimental SPR were derived for six pharmaceutical powders with brittle and ductile properties and compared to predicted SPR based on a three-stage approach. The prediction was based on the Kawakita b(-1) parameter and the in-die Heckel yield stress, an estimate of maximal tensile strength, and a parameter proportionality factor alpha. Three values of alpha were used to investigate the influence of the parameter on the SPR. The experimental SPR could satisfactorily be described by the three stage model, however for sodium bicarbonate the tensile strength plateau could not be observed experimentally. The shape of the predicted SPR was to a minor extent influenced by the Kawakita b(-1) but the width of the linear region was highly influenced by alpha. An increased alpha increased the width of the linear region and thus also the maximal predicted tablet tensile strength. Furthermore, the correspondence between experimental and predicted SPR was influenced by the alpha value and satisfactory predictions were in general obtained for alpha = 4.1 indicating the predictive potential of the hybrid approach.

• 出版日期2018-4