The future of whole-cell modeling

作者：Macklin Derek N; Ruggero Nicholas A; Covert Markus W^*

来源：Current Opinion in Biotechnology, 2014, 28: 111-115.

DOI：10.1016/j.copbio.2014.01.012

Integrated whole-cell modeling is poised to make a dramatic impact on molecular and systems biology, bioengineering, and medicine - once certain obstacles are overcome. From our group's experience building a whole-cell model of Mycoplasma genitalium, we identified several significant challenges to building models of more complex cells. Here we review and discuss these challenges in seven areas: first, experimental interrogation; second, data curation; third, model building and integration; fourth, accelerated computation; fifth, analysis and visualization; sixth, model validation; and seventh, collaboration and community development. Surmounting these challenges will require the cooperation of an interdisciplinary group of researchers to create increasingly sophisticated whole-cell models and make data, models, and simulations more accessible to the wider community.

• 出版日期2014-8