An easy-to-detect nona-arginine peptide for epidermal targeting

作者:Clede Sylvain; Delsuc Nicolas; Laugel Cecile; Lambert Francois; Sandt Christophe; Baillet Guffroy Arlette; Policar Clotilde*
来源:Chemical Communications, 2015, 51(13): 2687-2689.
DOI:10.1039/c4cc08737b

摘要

A correlative approach combining synchrotron radiation based IR microscopy and fluorescence microscopy enabled the successful detection and quantification of a nona-arginine peptide labelled with a Single Core Multimodal Probe for Imaging (SCoMPI) in skin biopsies. The topical penetration of the conjugate appeared to be time dependent and occurred most probably via the extracellular matrix.

  • 出版日期2015