A New i, i+3 Peptide Stapling System for alpha-Helix Stabilization

作者：Shim So Youn; Kim Young Woo; Verdine Gregory L^*

来源：Chemical Biology & Drug Design, 2013, 82(6): 635-642.

DOI：10.1111/cbdd.12231

• stapled peptides
• -helix
• ring-closing metathesis

We have previously shown that the incorporation of an 8-atom all-hydrocarbon staple' at positions i and i+3 of a synthetic peptide results in substantial stabilization of the -helical conformation. As part of our ongoing effort to explore the scope and utility of all-hydrocarbon stapling systems, we have investigated and report herein the properties of a new i, i+3 stapling system that employs a 6-carbon cross-link.

• 出版日期2013-12