Direct Analysis of Exhaled Breath of Chronic Hepatitis B Patients by Extractive Electrospray Ionization Mass Spectrometry

作者：Wang Hai Dong; Luo Jiao; Li Peng Hui; Zhu Lan Lan; Zhang Wei; Wu Xiao Ping^*; Zeng Qian; Ding Jian Hua

来源：Chinese Journal of Analytical Chemistry, 2015, 43(4): 507-512.

DOI：10.11895/j.issn.0253-3820.140954

• Chronic hepatitis B
• Exhaled breath
• Extractive electrospray ionization mass spectrometry
• Principal component analysis
• Cluster analysis

The exhaled breath samples of patients with chronic hepatitis B (41 cases) and healthy volunteers (34 cases) were detected by extractive electrospray ionization mass spectrometry (EESI-MS). After the process of MS data using principal component analysis (PCA) methods, the patients and normal subjects were distinguished effectively, and the PCA results were also validated for cluster analysis (CA). The results are helpful to the analysis of progression of chronic hepatitis B, and may provide bases for the development of a simple, rapid and noninvasive chnical diagnosis method for chronic hepatitis B.

• 出版日期2015-4
• 单位东华理工大学; 南昌大学