A novel ultrahigh-resolution surface plasmon resonance biosensor with an Au nanocluster-embedded dielectric film

作者：Hu WP; Chen SJ^*; Huang KT; Hsu JH; Chen WY; Chang GL; Lai KA

来源：Biosensors and Bioelectronics, 2004, 19(11): 1465-1471.

DOI：10.1016/j.bios.2003.12.001

• surface plasmon resonance
• optical biosensor
• Au nanoclusters
• surface-enhanced Raman scattering

The detection performance of conventional surface plasmon resonance (SPR) biosensors is limited to a 1 pg/mm(2) surface coverage of biomolecules, and consequently, such sensors struggle to detect the interaction of small molecules in low concentrations. The present study is attempted to propose the use of a novel SPR biosensor with An nanoclusters embedded in a dielectric film to achieve a 10-fold improvement in the resolution performance. A co-sputtering method utilizing a multi-target sputtering system is used to fabricate the present dielectric films (SiO2) with embedded An nanoclusters. It is shown that the sensitivity of the developed SPR biosensor can be improved by adjusting the size and volume fraction of the embedded Au nanoclusters in order to control the surface plasmon effect. The present gas detection and DNA hybridization experimental results confirm that the proposed Au nanocluster-enhanced SPR biosensor provides the potential to achieve surface coverage of biomolecules. an ultrahigh-resolution detection performance of approximately 0.

• 出版日期2004-6-15
• 单位中央民族大学