科研之友
微信
新浪微博
Facebook
分享链接
摘要
Background: There are grounds to believe that the course of bipolar disorder may be different in tropical countries such as India when compared to temperate nations. There is a dearth of literature about the course of bipolar l disorder from India. Methods: This study was conducted in a multispecialty teaching hospital in southern India. Patients with a DSM-IV TR diagnosis of bipolar I disorder, confirmed using SCID-I, with a minimum duration of illness of 3 years were assessed. Information was gathered on demographic and clinical variables, and the life course of episodes was charted using the National Institute of Mental Health - Life Chart Methodology Clinician Retrospective Chart (NIMI-I-LCM-CRC). Results: A total of 150 patients with bipolar disorder were included. The mean age at onset of illness was 24.8 (+/- 8.2) years. Mania was the first episode in a majority (85%) of the cases, and was the most frequent episode in the course of the illness, followed by depression. Patients spent an average of 11.1% of the illness duration in a mood episode, most commonly a manic episode. The median duration of manic or depressive episode was 2 months. Median time to recurrence after the first episode was 21 months (inter quartile range of 10-60 months), and was shorter for women than men. Limitations: The hospital based sample from a particular region limits gencralizability. Recall bias may be present in this retrospective information based study. Medical illness, personality disorders, other Axis l psychiatric disorders (apart from substance use disorder) and influence of adherence to treatment on the course of the disorder were not assessed systematically. Conclusions: Bipolar I disorder among Indian patients has a course characterized by predominantly manic episodes, which is in line with previous reports from tropical countries and substantially different horn that or temperate regions.
- 出版日期2015-3-1
