Ag/ZnO Nano-composites as Novel Antibacterial Agent against Strain of MRSA

作者：Mirershadi Fatemeh; Jafari Alireza^*; Janati Elham; Roohi Elham; Sarabi Mehrdad

来源：Journal of Pure and Applied Microbiology, 2013, 7(2): 947-956.

• Antibacterial Activity
• Ag/ZnONanocomposites
• MRSA

With the appearance of microbial organisms resistant to multiple antibiotics, also, increase nosocomial infection, specially by Methicillin Resistant Staphylococcus aureus (MRSA), antibacterial effects of Nanocompositeshave attended by the many researchers in recent years. We report the synthesis of binary Nano-metal oxides such as Ag/ZnONanocomposites also, Ag and ZnONanocompositesvia novel methods of thermal decomposition of oxalate precursor. XRD, FTIR, SEM and TEM were used to the thermal spectroscopic, structural, morphological characterization and surface area determination of the product, respectively. Strain of MRSA is prepared from ArdabilMedical University. Bacterial sensitivity to Nanocomposites was specially tested using by disc diffusion test and agar dilution test, and also with MIC, and MBC, against MRSA. The particle size was 12 nm, approximately. We reported that value of MIC Ag/ZnO bear on the MRSA was 8 mu g/ml. Albeit, the value of MIC bear on the standard strain of Staphylococcus aureus(ATCC 1113) was 128 mu g/ml. It is worthly noting that the value of MBC bear on the MRSA and the standard strain of Staphylococcus aureus were 128 mu g/ml and 2048 mu g/ml. The evidence was revealed that the antibacterial activity of Ag/ZnO were more vigorous to MRSA.

• 出版日期2013-6