A light-regulated synthetic ion channel constructed by an azobenzene modified hydraphile

作者：Yang, Rong-Yan; Bao, Chun-Yan^*; Lin, Qiu-Ning; Zhu, Lin-Yong

来源：Chinese Chemical Letters, 2015, 26(7): 851-856.

DOI：10.1016/j.cclet.2015.05.010

• Synthetic ion channel
• Light-regulated ion transport
• Hydraphiles
• Azobenzene photoisomerization
• Self-assembly

Biological ion channels are key molecules for cellular regulation and communication. To mimic the structure and functions of nature ion channels, a new class of light-regulated transmembrane ion channels was reported based on tri(macrocycle) hydraphile and azobenzene photoswitch (hydraphile 1). The liposome-based proton transport assays showed that hydraphile I exhibited excellent transmembrane activity (10, and Y-max arrived 0.7 at 401 mu mo1/L. The successful isomerization of azobenzene moiety was confirmed and qualified by UV and NMR spectra. Upon alternative irradiation of 365 nm UV light and 450 nm visible light, the transmembrane activity of hydraphile I was regulated between 0.35 and 0.5, reversibly. All the obtained results have demonstrated the promise of developing excellent synthetic ion channels with ion gating properties based on simple molecular design. 2015 Chinese Chemical Society and Institute of Materia Medica, Chinese Academy of Medical Sciences. Published by Elsevier B.V.

• 出版日期2015-7
• 单位华东理工大学