delta-Di-carboxybutyl phosphoramidate of 2 '-deoxycytidine-5 '-monophosphate as substrate for DNA polymerization by HIV-1 reverse transcriptase

作者：Zlatev Ivan; Giraut Anne; Morvan Francois^*; Herdewijn Piet; Vasseur Jean Jacques

来源：Bioorganic & Medicinal Chemistry, 2009, 17(19): 7008-7014.

DOI：10.1016/j.bmc.2009.08.001

• Polymerase
• Modified nucleotide
• Nucleotide analog
• Phosphoramidate
• HIV

The replacement of the pyrophosphate moiety of 2'-deoxynucleoside triphosphates by non natural delta-dicarboxylic butyl amino acid allows incorporation of natural 2'-deoxycytidine into DNA using HIV-1 reverse transcriptase (RT) as enzyme. In contrast, the 3'-deoxycytidine analogue was not a substrate of the HIV-1 RT.

• 出版日期2009-10-1
• 单位河北医科大学