Association between resistin+299A/A genotype and nonalcoholic fatty liver disease in Chinese patients with type 2 diabetes mellitus

作者：Zhang, Ling-Yun^*; Jin, Yong-Jun; Jin, Qing-Song; Lin, Liang-Yan; Zhang, Dong-Dong; Kong, Li-Li

来源：Gene, 2013, 529(2): 340-344.

DOI：10.1016/j.gene.2013.08.001

• Adipocytokine
• Insulin resistance
• Non-alcoholic fatty liver disease
• Single nucleotide polymorphism

Objective: To investigate the relationship between the resistin intronic +299G/A polymorphism and nonalcoholic fatty liver disease (NAFLD) in patients with type 2 diabetes mellitus (T2DM). @@@ Methods: We selected 738 T2DM patients, including 395 with NAFLD and 343 without fatty liver disease, as well as 279 healthy control individuals, and analyzed their resistin + 299G/A polymorphism genotype by polymerase chain reaction-restriction fragment length polymorphism. @@@ Results: Plasma resistin levels in T2DM patients with NAFLD were at the highest (P < 0.05). The frequency of AA genotype at the +299 site of the resistin gene in patients with concurrent T2DM combined with NAFLD was significantly different from that in the control (P < 0.05). The AA genotype was found to be associated with a 1.80-fold increased risk for T2DM combined with NAFLD, 2.05-fold increased risk for obesity and 2.37-fold increased risk for obesity of abdominal type compared to the GG (P < 0.05, respectively). The multivariate non-conditional logistic regression model analysis further shows that the M genotype is a risk factor for the development of NAFLD in T2DM patients (OR, 2.32; 95% Cl, 1.05-4.68; P < 0.05). @@@ Conclusion: The resistin +299AA genotype may be associated with increases in the risk of the NAFLD development in T2DM patients.

• 出版日期2013-10
• 单位滨州医学院