Adiponectin inhibits lymphotoxin-β receptor-mediated NF-κB signaling in human umbilical vein endothelial cells

作者：Xu, Yizhou^*; Zhang, Chu; Wang, Ningfu; Ling, Feng; Li, Peizhang; Gao, Yan; Hua, Wei

来源：Biochemical and Biophysical Research Communications, 2011, 404(4): 1060-1064.

DOI：10.1016/j.bbrc.2010.12.110

• Adiponectin
• AdipoR1
• LTBR
• Yeast two-hybrid screen
• NF-kappa B

Adiponectin exerts anti-diabetic and anti-atherogenesis properties through its 2 receptors (AdipoR1 and AdipoR2). However, the signaling pathways responsible for the anti-inflammatory effects of adiponectin are largely unknown. In this study, we identified the lymphotoxin (LT)-beta receptor (LTBR) as an interacting partner of human AdipoR1 by using a yeast two-hybrid screening. The interaction between LTBR and AdipoR1 was confirmed by co-immunoprecipitation and co-localization analysis. Furthermore, adiponectin incubation inhibited lymphotoxin-induced NF-kappa B activation and the expression of adhesion molecules in human umbilical vein endothelial cells. These results indicated that AdipoR1 interacted with LTBR and mediated the inhibition of LTBR-activated NF-kappa B pathway.

• 出版日期2011-1-28
• 单位中国医学科学院阜外医院; 南京医科大学; 中国医学科学院北京协和医院