Hereditary Hemochromatosis Restores the Virulence of Plague Vaccine Strains

作者：Quenee Lauriane E; Hermanas Timothy M; Ciletti Nancy; Louvel Helene; Miller Nathan C; Elli Derek; Blaylock Bill; Mitchell Anthony; Schroeder Jay; Krausz Thomas; Kanabrocki Joseph; Schneewind Olaf^*

来源：Journal of Infectious Diseases, 2012, 206(7): 1050-1058.

DOI：10.1093/infdis/jis433

Nonpigmented Yersinia pestis (pgm) strains are defective in scavenging host iron and have been used in live-attenuated vaccines to combat plague epidemics. Recently, a Y. pestis pgm strain was isolated from a researcher with hereditary hemochromatosis who died from laboratory-acquired plague. We used hemojuvelin-knockout (Hjv(-/-)) mice to examine whether iron-storage disease restores the virulence defects of nonpigmented Y. pestis. Unlike wild-type mice, Hjv(-/-) mice developed lethal plague when challenged with Y. pestis pgm strains. Immunization of Hjv(-/-) mice with a subunit vaccine that blocks Y. pestis type III secretion generated protection against plague. Thus, individuals with hereditary hemochromatosis may be protected with subunit vaccines but should not be exposed to live-attenuated plague vaccines.

• 出版日期2012-10-1