科研之友
微信
新浪微博
Facebook
分享链接
摘要
Proneural genes control the generation of neuroblasts from the neuroepithelium, but their functions in neuroblast asymmetric division and migration remain elusive. Here, we identified Caenorhabditis elegans mutants of a proneural transcription factor (TF) lin-32, in which Q neuroblasts are produced. We showed that LIN-32 functions in parallel with a storkhead TF, HAM-1, to regulate Q neuroblast asymmetric division, and that Q neuroblast migration is inhibited in lin-32 alleles. Consistently, lin-32 is expressed throughout Q neuroblast lineage, suggesting that LIN-32 may promote different target gene expression. Our studies thus uncovered previously unknown functions of a proneural gene in neuroblast development.
