Glycerol salicylate-based containing -tricalcium phosphate as a bioactive root canal sealer

作者：Portella Fernando F; Collares Fabricio M^*; dos Santos Luis A; dos Santos Bruno P; Camassola Melissa; Leitune Vicente C B; Samuel Susana M W

来源：Journal of Biomedical Materials Research Part B: Applied Biomaterials , 2015, 103(8): 1663-1669.

DOI：10.1002/jbm.b.33326

• -tricalcium phosphate
• bioactive sealers
• glycerol
• salicylate
• Raman

The use of bioactive materials instead of inert materials to fill the root canal space could be an effective approach to achieve a hermetic seal and stimulate the healing of periapical tissues. The purpose of this study was to develop and characterize an endodontic sealer based on a glycerol salicylate resin and -tricalcium phosphate (TCP) at physical and chemical properties. Different sealers were formulated using 70% of a glycerol salicylate resin and 30% of a mixture of calcium hydroxide and TCP (0, 5, 10, or 15%, in weight). Sealers formulated were characterized based on setting time, in vitro degradation over time, pH, cytotoxicity, and mineral deposition. Sealers presented setting time ranging from 240 to 405 min, and basic pH over 8.21 after 28 days. Higher TCP concentration leads to sealers with low solubility. Cell viability after 48 h in direct contact with sealers was similar to a commercial sealer used as reference. The 10% and 15% TCP sealers exhibited a calcium-phosphate layer on the surface after immersion in water and SBF for 7 days. Glycerol salicylate sealers with 10% and 15% -tricalcium phosphate showed reliable physical-chemical properties and apatite-forming ability.

• 出版日期2015-11