Association of interferon-gamma gene polymorphism (+874A) with arthritis manifestation in SLE

作者：Tangwattanachulee**** Marut; Sodsai Pimpayao; Avihingsanon Yingyos; Wongpiyabovorn Jongkonnee; Wongchinsri Jeerapat; Hirankarn Nattiya^*

来源：Clinical Rheumatology, 2007, 26(11): 1921-1924.

DOI：10.1007/s10067-007-0699-6

• interferon-gamma
• polymorphisms
• SLE
• Thai population

Systemic lupus erythematosus (SLE) is a complex autoimmune disease in which genetic factors strongly influence susceptibility. Cytokines such as the interferon-gamma (IFNG) gene play a key role in controlling the immunity and inflammation, and therefore their polymorphisms may affect these genes' expression levels among individuals. We investigated the frequency of IFNG gene intron (+874) polymorphism, previously reported to be associated with IFNG production, in SLE patients compared to a control group. This population-based case-control study includes 154 SLE patients and 154 healthy control subjects with similar ethnic backgrounds. The genotyping was determined by polymerase chain reaction sequence-specific primer method and using the Chi-squared test for analyzing the association between this single-nucleotide polymorphism and SLE. The allele frequencies of the IFNG (+874) gene polymorphism were not significantly different between SLE patients and control subjects (72.7 vs 77%). However, there was a significant association between A dominance model of inheritance with arthritis (odds ratio=7.64, 95% confidence interval=1.56-41.64, P=0.006, P-c=0.03). The result suggested that the +874 intron polymorphism of IFNG can be used as the marker for SLE susceptibility with arthritis in the Thai population.

• 出版日期2007-11