A direct method for the synthesis of orthogonally protected furyl- and thienyl- amino acids

作者：Hudson Alex S; Caron Laurent; Colgin Neil; Cobb Steven L^*

来源：Amino Acids, 2015, 47(4): 779-785.

DOI：10.1007/s00726-014-1908-7

• Heteroaromatic amino acids
• Negishi cross-coupling
• Furyl-alanine
• Thienyl-alanine

The synthesis of unnatural amino acids plays a key part in expanding the potential application of peptide-based drugs and in the total synthesis of peptide natural products. Herein, we report a direct method for the synthesis of orthogonally protected 5-membered heteroaromatic amino acids.

• 出版日期2015-4