Gold nanourchins and celastrol reorganize the nucleo- and cytoskeleton of glioblastoma cells

作者:Maysinger Dusica; Moquin Alexandre; Choi Jason; Kodiha Mohamed; Stochaj Ursula
来源:Nanoscale, 2018, 10(4): 1716-1726.
DOI:10.1039/c7nr07833a

摘要

Gold nanourchins (AuNUs) associate with lysosomes and lipid droplets (LDs) in glioblastoma cells. AuNUs reorganize F-actin, microtubules and the nuclear lamina. This alters cell signaling and increases cell death. Cell injury is further enhanced by celastrol.

  • 出版日期2018-1-28
  • 单位Mcgill University